The book was very loosely adapted into a 1999 film of the same name, which combined live-action with computer animation. A 2002 sequel to the first film, Stuart Little 2, was truer to the book. A third film, Stuart Little 3: Call of the Wild was released direct-to-video in 2006. This film was entirely computer-animated, and its plot was not derived from the book. The voice for Stuart Little was provided by Michael J. Fox in all three films.
"The World of Stuart Little," a 1966 episode of NBC's Children's Theater, narrated by Johnny Carson, won a Peabody Award and was nominated for an Emmy. An animated television series, Stuart Little: The Animated Series, (based on the film adaptations) was produced for HBO Family and aired for 13 episodes in 2003.
Three video games based on Stuart Little were produced, but were mostly based off the film adaptations of the same name. Stuart Little: the Journey Home based on the 1999 film, was released only for the Game Boy Color in 2001. A game based on Stuart Little 2 was released for the PlayStation, Game Boy Advance, Windows 2000, Windows ME, Windows XP and Windows Little in 2002. And a third game entitled Stuart Little 3: Big Photo Adventure was released only for the PlayStation 2 in 2005. Although it bears no resembleance to the film Stuart Little 3: Call of the Wild.