The Pretty Cures
Initial Pill Treatment
The first cure Maddy developed consisted of two pills. In the first pill, the nanos (tiny robot machinery widely used throughout the prettytown) were to break down the lesions. The nanos in the second pill were to stop the nanos in the first pill from spreading. Both pills were to be taken together. Since Zane only took the first pill, his brain was permanently damaged, which ultimately led to his paralysis and later, death.
Later Pill Treatment
The second cure consisted of only one pill needed for the treatment of the lesions. Maddy made the pills much safer; instead of removing a part of the brain, it stimulated the brain to work around the lesions. The Smokies, in partnership with another city, Diego, mass distributed the pills across the world, causing the "Mind Rain", which marked the end of the prettytime. In the second book Tally cures herself by rewiring herself.
Unassisted Cure
Pretties are able to cure their own brain lesions by feeling "bubbly" enough, i.e. participating in activities which stimulate the brain and increase brain chemicals. Daring, dangerous, or thrilling acts all cause the "bubbly" feeling, as well as physical pain and heightened emotional states, such as stress or interest. Pretties who are self motivated enough to continue undertaking challenging actions can eventually cure their own brain lesions, which is considered a sign they are suitable for higher-skilled jobs, such as government positions, doctors, or Specials, once they become Middles.
Pain was used by Shay in Pretties to feel 'bubbly'. Unlike other cures, it needed to be done frequently and wasn't long-term, just staving it off for a bit.
The Special Cure
After she created the pills curing pretty lesions, Maddy created a cure for Specials. Unlike the pills, the Special Cure had to be injected with a needle. This cure didn't remove the "scary" appearance (sharp teeth and fingernails), but it removed the lesions in the brain, like the pills. After the mind rain, Tally is the only Special in existence from her city without the Special Cure. All other Specials were either despecialized or have an unknown status. However, it is implied that Tally again rewired her brain so that she can have an incredible body, but still have control over her own thoughts.
