The novel was made into the 1983 Disney film Something Wicked This Way Comes, with Bradbury as the screenwriter. In a later interview, Bradbury said that he considered the film one of the better adaptations of his works.
Bradbury's Pandemonium Theatre Company also debuted a play based on the novel in Los Angeles on October 1, 2003, directed by Alan Neal Hubbs, also associated with the 1970 stage adaptation of Bradbury's The Martian Chronicles. The main cast was Grady Hutt as Will Halloway, J. Skylar Testa as Jim Nightshade, Jay Gerber as Charles Halloway, and Mark Aaron as Mr. Dark. Critics gave the play generally favorable reviews, stating that it captured the lyricism and dark tone of the novel. They also praised its special effects, which included a carousel constructed of mirrors with actors as the horses, and Jay Gerber as Charles Halloway. Sharon Perlmutter of Talkin' Broadway, however, said that Hutt and Tests gave bland performances as the two lead characters.
Something Wicked This Way Comes was produced as a full-cast radio play by the Colonial Radio Theatre on the Air, and released by Blackstone Audio on October 1, 2007. Ray Bradbury wrote the script, modified for audio from his stage play. The cast includes Jerry Robbins as Mr. Halloway, J.T. Turner as Mr. Dark, Anastas Varinos as Will Halloway, and Matthew Scott Robertson as Jim Nightshade. This production was directed by Nancy Curran Willis, with music by Jeffrey Gage and post-production by Chris Snyder.
Something Wicked This Way Comes was produced as a radio play for the BBC Radio 4 Saturday Play series and was broadcast on 29 October 2011. The production was adapted for radio by Diana Griffths and produced/directed by Pauline Harris with music by David Paul Jones and sound by Paul Cargill. The cast included Theo Gregory as Will, Josef Lindsay as Jim, Henry Goodman as Charles Halloway, Gerard McDermott as Mr. Cooger/The Lightning Rod Salesman and Kenneth Cranham as Mr. Dark.