The novel has been adapted into a film by director Martin Scorsese, starring Leonardo DiCaprio as Teddy Daniels, Mark Ruffalo as Chuck Aule, Ben Kingsley as Dr. Cawley, and Max von Sydow as Dr. Naehring.
The film was originally scheduled to be released by Paramount Pictures on October 2, 2009, in the United States and Canada. Paramount later announced it was going to push back the release date to February 19, 2010; reports attribute the pushback to Paramount's not having "the financing in 2009 to spend the $50 to $60 million necessary to market a big awards pic like this," DiCaprio's unavailability to promote the film internationally, and Paramount's hope that the economy might rebound enough by February 2010 that a film geared toward adult audiences would be more viable financially.
The film opened #1 at the box office with $41 million, according to studio estimates. The movie gave Scorsese his best box office opening yet.
The film remained #1 in its second weekend with $22.2 million. Eventually, the film grossed $128,012,934 in North America and $166,790,080 in foreign markets, for a total of $294,803,014, becoming Scorsese's highest-grossing film worldwide until The Wolf of Wall Street.
The HarperCollins audiobook version of the novel is read by David Strathairn.
The Audible Audio Edition version of the novel is read by Tom Stechschulte.
The story has also been reworked into a graphic novel published by William Morrow, with art by Christian de Metter (ISBN 0-06-196857-9).