How do the Friar's opening lines in scene 3 remind the reader that Romeo seems fated for ill- fortune?

In the opening lines of Act III, Scene III, the Friar notes Romeo's propensity for bad luck, meaning that whatever he does, it always seems to end in trouble.

Romeo, come forth; come forth, thou fearful man:
Affliction is enamour'd of thy parts,
And thou art wedded to calamity.