Thom Yorke cites the film as one of the inspirations for the Radiohead song "Exit Music (For a Film)", which was written specifically for the ending credits of the 1996 film William Shakespeare's Romeo + Juliet. Said Yorke, "I saw the Zeffirelli version when I was 13, and I cried my eyes out, because I couldn't understand why the morning after they shagged, they didn't just run away. The song is written for two people who should run away before all the bad stuff starts. A personal song."
Kevin and Paul go to see the film in the episode "Wayne on Wheels" in season three of The Wonder Years.
Celine Dion referenced this film, in particular the "hand dance" scene, in the video for her 1992 single "Nothing Broken but My Heart".
Japanese manga artist Rumiko Takahashi referenced the Zeffirelli film in two of her manga and anime works. In one episode of Urusei Yatsura, devious troublemaker Ryoko Mendou invites the series' male protagonist, Ataru Moroboshi, to have a "Romeo and Juliet" rendezvous with her, and wears a dress based on Hussey's from the film. Later, Takahashi's Ranma 1/2 featured a storyline in which the lead characters, Ranma Saotome and Akane Tendo, are cast as Romeo and Juliet in a production of the play at their high school. Takahashi designed Ranma and Akane's costumes for the play with Whiting and Hussey's outfits in the Zeffirelli film in mind.