Entertainment Weekly reviewed Pride and Prejudice and Zombies favorably, giving it a grade of A−. Library Journal recommended the novel "...for all popular fiction collections". The A.V. Club gave the novel a grade of A, commenting that "(w)hat begins as a gimmick ends with renewed appreciation of the indomitable appeal of Austen’s language, characters, and situations..." The New Yorker's Macy Halford, however, called the book's estimated blend of eighty-five percent Austen's words and fifteen percent Grahame-Smith's "one hundred per cent terrible"; while she admitted that the mashup may have accurately identified a subtextual theme of "mystery and menace" in the original novel, she still found Grahame-Smith's writing to be awful, singling out a passage in which Elizabeth Bennett prepares to kill Mr. Darcy over an overheard slight.
As of April 9, 2009, Pride and Prejudice and Zombies was number three on the New York Times bestseller list. On the same morning, the book moved on amazon.co.uk's bestseller list from the 300s to 27th place. Before the book was published in the United Kingdom, the book required a second printing.