In May 2010, Pride and Prejudice and Zombies: The Graphic Novel was published by Del Rey / Random House, with acclaimed comic writer Tony Lee adapting the text and art by Cliff Richards.
In October 2011, an interactive ebook version produced by PadWorx Digital Media Inc. was released.
In June 2010, an app based on Pride and Prejudice and Zombies was released for the iPod Touch and iPhone. Digital development specialist Freeverse is behind the app, and describes the title as "a rollicking action title with the perfect blend of zombie slaying action and touching romance narrative".
A film adaptation has been in conversation since February 2009, when the British press (The Sunday Times) reported that Hollywood was bidding to turn Pride and Prejudice and Zombies into a blockbuster film. At a book-signing held at California State University Fullerton on April 23, 2009, Grahame-Smith said the novel had officially been purchased by an undisclosed major film company to be produced as a feature film.
Lionsgate originally planned to finance and distribute the film, with Natalie Portman playing the lead role, but she later reconsidered and decided to serve as a producer instead. In addition, David O. Russell would have directed; however, he left production due to scheduling conflicts. Mike White was hired to direct the adaptation, but he also left the project in January 2011 due to scheduling conflicts. Craig Gillespie finalized a contract to direct the film on April 18, 2011, but left the project in October.
On May 2, 2013, Lily James confirmed that the film was still in the works and announced that she would star in the film as a leading role. The project was also set to feature extensive involvement from Burr Steers. On August 4, 2014, it was announced that filming would begin in September, with Lily James as Elizabeth, Sam Riley as Mr. Darcy, and Bella Heathcote as one of Elizabeth's sisters. Jack Huston joined the cast as Mr. Wickham. Douglas Booth joined the cast as Mr. Bingley. Matt Smith joined the cast as Mr. Collins, with shooting scheduled to begin on September 24. On September 23, 2014, it was announced that Game of Thrones' Charles Dance and Lena Headey had joined the cast, and that Screen Gems purchased the rights to release it in the United States.
Pride and Prejudice and Zombies was released on February 5, 2016 to mixed critical reviews and commercial failure, grossing $16.4 million worldwide from a $28 million budget.