How does this quote relate to any characters in the book?

Alas, thrice-gentle Cassio, My advocation is not now in tune. My lord is not my lord, nor should I know him Were he in favor as in humor altered. So help me every spirit sanctified As I have spoken for you all my best And stood within the blank of his displeasure For my free speech. You must awhile be patient. What I can do I will, and more I will Than for myself I dare. Let that suffice you.
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Desdemona is saying this to Cassio. She says that she has pleaded his case to Othello three times with no success. She says that Othello's personality has changed as of late and he grows more and more aggressive when she tries to reason with him.