The argument needs to be explained and then either defended or refuted. The argument needs to be important.
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This is largely a thematic question, so there are a few arguments you might consider. I am partial to Atwoods's theme about the corruption of nature.
The theme of "natural" evolution vs. "synthetic" evolution is presented in Oryx and Crake numerous times. The pharmaceutical companies in the novel have gone beyond creating medicines to battle disease and bodily dysfunction. Their expansion into genetically modified animals raises questions about what exactly comprises nature. Crake describes his modification of human beings as a part of nature as in his view, nothing lies outside of the realm of nature.
The theme of nature is most poignantly explored in the last chapter of the book. Upon seeing three other surviving humans, Snowman has to decide which population, human or Craker, will have the chance to prosper. His decision, which is not revealed in the text, raises questions about human nature and the future evolution of the various surviving species. You can find more themes at the link below: