Of Mice and Men was Steinbeck's first attempt at writing in the form of novel-play termed a "play-novelette" by one critic. Structured in three acts of two chapters each, it is intended to be both a novella and a script for a play. He wanted to write a novel that could be played from its lines, or a play that could be read like a novel.
Steinbeck originally titled it Something That Happened (referring to the events of the book as "something that happened" because nobody can be really blamed for the tragedy that unfolds in the story), however, he changed the title after reading Robert Burns's poem To a Mouse. Burns's poem tells of the regret the narrator feels for having destroyed the home of a mouse while plowing his field.
Steinbeck wrote this book and The Grapes of Wrath in what is now Monte Sereno, California. An early draft of the novel was eaten by Steinbeck's dog, named Max.