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George tells Lennie they're different after telling him how great it would be without him around. Although he complains about Lennie, he also cares for him deeply. Their relationship is rare in the world of farm workers. From the text:
George went on. "With us it ain’t like that. We got a future. We got somebody to talk to that gives a damn about us. We don’t have to sit-in no bar room blowin’ in our jack jus’ because we got no place else to go. If them other guys gets in jail they can rot for all anybody gives a damn. But not us."
Of Mice and Men