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I think, on the surface, one might blame Curley's wife. When examining Steinbeck's masterpiece as a whole, we find that she (Curley's wife) was just as much a victim of circumstance than any other of the lonely depressed characters, even more so.
Whenever Curley's wife shows up we see her loneliness. It pours out of her in resentment and disillusion.
"I never get to talk to nobody. I get awful lonely."
"What's the matter with me? Ain't I got a right to talk to nobody?"
"Seems like they ain't none of them cares how I gotta live".
Try to read what she is saying here. She blames others (rightly so) but feels so disenfranchised that she does not know who she is anymore. So, in the end, we can't blame a desperate rather immature woman for events to unravel. In Steinbeck's world, events would have unraveled anyway.