North by Northwest was nominated for three Academy Awards for Best Film Editing (George Tomasini), Best Production Design (William A. Horning, Robert F. Boyle, Merrill Pye, Henry Grace, Frank McKelvy), and Best Original Screenplay (Ernest Lehman) at the 32nd Academy Awards ceremony. Two of the three awards went instead to Ben-Hur, and the other went to Pillow Talk. The film also won a 1960 Edgar Award for Best Motion Picture Screenplay, for Lehman.
In 1995, North by Northwest was selected for preservation in the National Film Registry by the United States Library of Congress as being "culturally, historically, or aesthetically significant."
In June 2008, the American Film Institute revealed its "10 Top 10"—the best ten films in ten "classic" American film genres—after polling over 1,500 people from the creative community. North by Northwest was acknowledged as the seventh-best film in the mystery genre. It was also listed as No. 40 in AFI's 100 Years...100 Movies, No. 4 in AFI's 100 Years...100 Thrills, and No. 55 in AFI's 100 Years...100 Movies (10th Anniversary Edition).