The play premièred at the Lyric Theatre, Hammersmith, London in 1982, directed by Michael Blakemore and starring Patricia Routledge, Paul Eddington, and Nicky Henson. It opened to universally ecstatic reviews and shortly after transferred to the Savoy Theatre in the West End, where it ran until 1987 with five successive casts. It won the Evening Standard Award for Best Comedy.
On 11 December 1983, a production directed again by Blakemore and starring Dorothy Loudon, Victor Garber, Brian Murray, Deborah Rush, Douglas Seale, and Amy Wright opened in New York City at the Brooks Atkinson Theatre, on Broadway, where it ran for 553 performances. It earned Tony Award nominations for Best Play and for Blakemore, Rush, and Seale, and won a Drama Desk Award for Outstanding Ensemble.
Noises Off has become a staple of both professional theatre companies and community theatres on both sides of the Atlantic. On 5 October 2000, the National Theatre in London mounted a revival, directed by Jeremy Sams and starring Patricia Hodge, Peter Egan and Aden Gillett, that ran for two years, transferring to the Piccadilly Theatre in the West End on 14 May 2001 with Lynn Redgrave and Stephen Mangan replacing Hodge and Egan, respectively. Sams' production transferred to Broadway, again at the Brooks Atkinson, on 1 November 2001, with Patti LuPone, Peter Gallagher, Faith Prince, T.R. Knight, and Katie Finneran. The production was nominated for a Tony and Drama Desk Award as Best Revival of a Play, and Finneran was named Best Featured Actress by both groups.
Frayn has repeatedly rewritten the play over the years. The last revision was in 2000 at the request of Jeremy Sams. There are numerous differences between the 1982 and 2000 scripts. Some new sequences have been added (e.g., an introduction to Act Three, in which Tim, the Company Stage Manager, and Poppy, the Assistant Stage Manager, make simultaneous apologies – the former in front of the curtain, the latter over the PA – for the delay in the performance). Other sequences have been altered or cut entirely. References that tend to date the play (such as Mrs. Clackett's to the Brents having colour television) have been eliminated or rewritten.
The most recent revival ran from 3 December 2011 to 10 March 2012 at the Old Vic Theatre, directed by Lindsay Posner and starring Jonathan Coy, Janie Dee, Robert Glenister, Jamie Glover, Celia Imrie, Karl Johnson, Aisling Loftus, Amy Nuttall and Paul Ready. This production transferred to the Novello Theatre in the West End from 24 March to 30 June 2012, and then toured Britain and Ireland with a different cast.