Since the 1960s, numerous filmmakers considered adapting Naked Lunch for the screen. Antony Balch, who worked with Burroughs on a number of short film projects in 1960s, considered making a musical with Mick Jagger in the lead role, but the project fell through when relationships soured between Balch and Jagger. Burroughs himself adapted his book for the never-made film; after Jagger dropped out, Dennis Hopper was considered for the lead role, and at one point game-show producer Chuck Barris was considered a possible financier of the project.
In 1991, Canadian director David Cronenberg took up the challenge. Rather than attempting a straight adaptation, Cronenberg took a few elements from the book and combined them with elements of Burroughs' life, creating a hybrid film about the writing of the book rather than the book itself. Peter Weller starred as William Lee, the pseudonym Burroughs used when he wrote Junkie.