Metropolis features a range of elaborate special effects and set designs, ranging from a huge gothic cathedral to a futuristic cityscape. In an interview, Fritz Lang reported that "the film was born from my first sight of the skyscrapers in New York in October 1924". He had visited New York for the first time and remarked "I looked into the streets – the glaring lights and the tall buildings – and there I conceived Metropolis." Describing his first impressions of the city, Lang said that "the buildings seemed to be a vertical sail, scintillating and very light, a luxurious backdrop, suspended in the dark sky to dazzle, distract and hypnotize". He added "The sight of Neuyork [sic] alone should be enough to turn this beacon of beauty into the center of a film"
The appearance of the city in Metropolis is strongly informed by the Art Deco movement; however it also incorporates elements from other traditions. Ingeborg Hoesterey described the architecture featured in Metropolis as eclectic, writing how its locales represent both “functionalist modernism [and] art deco” whilst also featuring “the scientist’s archaic little house with its high-powered laboratory, the catacombs [and] the Gothic cathedral”. The film’s use of art deco architecture was highly influential, and has been reported to have contributed to the style’s subsequent popularity in Europe and America.
The film drew heavily on biblical sources for several of its key set-pieces. During her first talk to the workers, Maria uses the story of the Tower of Babel to highlight the discord between the intellectuals and the workers. Additionally, a delusional Freder imagines the false-Maria as the Whore of Babylon, riding on the back of a many-headed dragon. Also, the name of the Yoshiwara club alludes to the famous red-light district of Tokyo.