What does Macduff's reaction, "he has no children" mean

Act 4 scene 3 line 184

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Macduff has just found out his family (children included) has been slaughtered by Macbeth. Malcolm keeps telling Macduff to "dispute it like a man" and get revenge. Macduff says he could never fully avenge Macbeth because Macbeth has no children to kill.