reversal of the natural order as in unnatural things that happen in the play.
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Certainly the opening witch scenes shows abnormal order. The weather is bad and the witches uses dark spells and animal spirits to practice their dark arts. Macbeth becoming Thane of Cawdor is another disturbance in the natural order of the universe. The thane of Cawdor betraying his king was considered to be an act most unnatural and abhorred to God. Lady Macbeth wanting to be a man, so she can do bloody deeds, would have been considered most unnatural as well.