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Gender roles were pretty much set in stone during Shakespeare's time. Women are considered emotional, nurturing, and fragile where men are considered stoic, strong, and masculine. Lady Macbeth laments her gender while she hatches her plan to kill King Duncan, "Come to my woman's breasts,. And take my milk for gall..." Macbeth on the other hand is sensitive towards his King,
"Who should against his murderer shut the door,. Not bear the knife myself. Besides, this Duncan. Hath borne his faculties so meek..."
Of course these roles reverse as the play goes on and eventually Macbeth and his wife become consumed by the frailties their gender are supposed to have.