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How about one of the most famous metaphors in the play? Check this out,
Will all great Neptune's ocean wash this blood
Clean from my hand? No, this my hand will rather
The multitudinous seas in incarnadine,
Making the green one red.
Yes, Macbeth’s conscience is so charged with guilt that, should he wash them in the sea, his bloody hands will turn the sea to the colour red. Macbeth needs some major therapy!