In 1930, a British film adaptation of the play was produced which was directed by Alfred Hitchcock. In the United States, it was also known by the title "The Shame of Mary Boyle."
- Barry Fitzgerald as The Orator
- Maire O'Neill as Mrs Maisie Madigan
- Edward Chapman as Captain Boyle
- Sidney Morgan as 'Joxer' Daly
- Sara Allgood as Mrs Boyle ('Juno')
- John Laurie as Johnny Boyle
There are three television adaptions of Juno and the Paycock:
- 1938: Starring Maire O'Neill as Juno and Harry Hutchinson as Captain Jack.
- 1960: Starring Hume Cronyn and Walter Matthau.
- 1980: Starring Frances Tomelty as Juno and Dudley Sutton as Captain Jack.
A musical adaptation of the play, titled Juno, was created by Marc Blitzstein (music, lyrics) and Joseph Stein (book) and opened on Broadway in 1959. Shirley Booth starred as Juno Boyle and Melvyn Douglas as the Captain. The musical version was a flop, closing after 16 performances, but Blitzstein's score was preserved on the original cast album and is today considered one of the composer's masterpieces. O'Casey gave his blessing to the project, but never saw the production.
- Shirley Booth as Juno Boyle
- Melvyn Douglas as Captain Boyle
- Jack MacGowran as Joxer
- Tommy Rall as Johnny Boyle 
A new production was broadcast 16 November 2014 on BBC Radio 3 directed by Peter Kavanaugh with:
- Sorcha Cusack as Juno Boyle
- Stanley Townsend as Captain Boyle
- John Kavanaugh as Joxer
- Beth Cooke as Mary Boyle
- Rory Fleck Byrne as Johnny Boyle
- Michele Moran as Maisie Madigan
A recording of the play was made by Cyril Cusack Productions, Ireland, in Dublin in June 1955, in connection with the Abbey Theatre, and was issued commercially on an LP double album. The performance has a spoken introduction by the author. The cast included:
- Séamus Caomhánach as Captain Jack
- Siobhán McKenna as Juno Boyle
- Cyril Cusack as Joxer Daly
- Maire Kean as Mrs Maisie Madigan
- Leo Leyden as Jonny Boyle
- Maureen Cusack as Mary Boyle