The world-famous German director Peter Stein directed a landmark production of Im Dickicht der Städte at the Munich Kammerspiele in 1968, when he was Assistant Director there, and before he founded the very influential Schaubühne am Halleschen Ufer in West Berlin a few years later. Dieter Laser, known to English-speaking audiences for his role as Dr. Josef Heiter in The Human Centipede (2010), made his filim debut in the role of Collie Couch.
Al Pacino starred in a short-lived production at the Circle in the Square Theatre in New York in 1979, directed by the famous Romanian director Liviu Ciulei.
Judith Malina directed a Living Theatre production of the play in New York, opening on 16 December 1960. In October 1991, Ruth Berghaus directed the play at the Thalia Theater in Hamburg as part of a series of 'related texts', as she called them (which also included Büchner's Danton's Death).