Composing team Benj Pasek and Justin Paul working alongside book writer Timothy Allen McDonald adapted James And The Giant Peach for the stage as a musical. The show began development in 2004.
The musical premiered in October 2010 at Goodspeed Musicals in East Haddam, Connecticut. The musical itself was quite different from its source material, but honored it. Throughout the two month run, the show underwent lots of renovation. The cast featured young stars Justin Lawrence Hall and Ellis Gage playing James, Broadway veteran Steve Rosen as Marvo The Magician, Ruth Gotchall as Aunt Spiker and Denny Dillon as Aunt Sponge. The show also featured Jim Stanek as the Grasshopper, Chelsea Krombach as the Ladybug, Kate Wetherhead as the Spider, Destan Owens as the Earthworm, Nick Gaswirth as the Centipede, also with Nicholas Park, Minami Yusi, Marissa Palley, and Jessica Hershberg in the Ensemble. The dance troupe "Pilobolus" were a large part of the production bringing an innovative theatrical technique of using their bodies to create most of the set, specifically using shadow technique to create a majority of the special effects.
In November 2013, a completely reworked version of the show was presented at the Seattle Children's Theatre.  After the 2010 production, the show underwent much revision, altering plot aspects and songs to appeal to a younger audience, the most notable of which were the omitting of its former title song, "Perfectly Perfect", the casting of an adult in the title role, and the discontinuation of the use of "Pilobolus". The set was also more elaborate than its Goodspeed counterpart. Mike Spee played James, Wicked veteran Kendra Kassebaum played the Ladybug, and Julie Briskman and Jayne Muirhead played Sponge and Spiker, respectively. The cast also featured Rich Gray as Centipede, Heath Saunders as Earthworm, Greg McCormick Allen as Grasshopper, Diana Huey as Spider, Julie Briskman as Sponge and Jayne Muirhead as Spiker, with Vickielee Wohlbach, Ian Lindsay and Auston James in the Ensemble
The 2013 version acted as a final draft for the version of the show that is currently available for licensing by Music Theater International.