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He is responsible only in the sense that he mskes some choices which he thinks will change his life and the "invisibility" he seems to feel. The society and its treatment of Griffin as a black man is really what puts him in the position of one who is invisible and one who wishes to change that status.
Instead of just feeing invisible or an outcast , Wells makes Griffin literally invisible. Much of Griffin's isolation is self-inflicted. He has the traits many of us share (temper, impatience, rage) but turns up the intensity on these emotions. Griffin's penchant for taking drugs as a stimulant, add to his aggression and paranoia. His fear and superstition become a defense mechanism to justify being invisible and committing various acts of carelessness and crime. While Griffin would have been wise to leave the invisibility to his cat, he tries his potion on his cat first, he takes his chemical concoction like some Faustian bargain that he will eventually regret. Griffin lets his emotions and vices control and eventually destroy him. Although Griffin's decline lonely and sad, much of it is of his own making.