- HeadOn, a homeopathic product claimed to relieve headaches
- Head-on collision
- Head On (video game), a 1979 arcade game by Sega
- Head On N, Nintendo's version of the above arcade game
- Head On, a 1994 autobiography by musician Julian Cope
- Head On, a 2007 autobiography by cricketer Ian Botham
- Headon, a settlement in Bassetlaw, England
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