- Greg Heffley is a middle school student, who is the main character and narrator of the series. He is an anti-hero, described by Kinney as "cocksure" and "misguided".[16]
- Rowley Jefferson is Greg's good-natured best friend.
- Rodrick Heffley is Greg and Manny's older brother, who is rude, and the drummer in his band Löded Diper. He usually is noted for playing tricks on Greg.
- Manny Heffley is Greg and Rodrick's spoiled younger brother, who is known to be a tattletale.
- Susan Heffley is Greg's mother. She often embarrasses Greg.
- Frank Heffley is Greg's father. He always wants Greg to do sports and "to become a man", and doesn't like giving up.
- Gramma is Greg's maternal grandmother.
- Grandpa is Greg's paternal grandfather who is sometimes noted for irritating Greg.
- Fregley is Greg's odd neighbor and classmate.
- Chirag Gupta is one of Greg's friends whom he once played a trick on, pretending Chirag to have been invisible, then later pretended he was going deaf.
- Holly Hills is Greg's crush.
- Heather Hills is Holly's sister, and was Greg and Rodrick's crush.
- Patty Farrell is Greg's rival in school.
- Sweetie is the name given to the Heffleys' temporary dog, who annoys Greg. Later on, they give him to Gramma, who spoils him and is the cause of him becoming overweight.
- An unnamed pig was won by Manny at a county fair. The pig displays high intelligence, and walks upright. In The Getaway, the family put the pig in a kennel while they went on vacation but the pig escaped and hasn't been seen again.
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