- Don Cheadle as Detective Graham Waters, a black officer investigating recent murders based on racial tensions
- Sandra Bullock as Jean Cabot, Rick's wife
- Matt Dillon as Sergeant John Ryan, a bigoted police officer
- Jennifer Esposito as Ria, Graham's Hispanic partner
- Brendan Fraser as District Attorney Rick Cabot, Jean's husband
- Terrence Howard as Cameron Thayer, a television director and Christine's husband
- Ludacris as Anthony, a violent carjacker and Peter's partner
- Thandiwe Newton (credited as Thandie Newton) as Christine Thayer, Cameron's wife
- Michael Peña as Daniel Ruiz, a Hispanic locksmith
- Ryan Phillippe as Officer Tom Hansen, a rookie policeman and Ryan's partner
- Larenz Tate as Peter, a laid back carjacker, and Anthony's partner
- Shaun Toub as Farhad, a Persian shop owner
- Bahar Soomekh as Dorri, Farhad's daughter
- Ashlyn Sanchez as Lara Ruiz, Daniel's daughter
- Karina Arroyave as Elizabeth Ruiz, Daniel's wife
- Loretta Devine as Shaniqua Johnson, a HMO administrator
- Beverly Todd as Mrs. Waters
- William Fichtner as Jake Flanagan, Rick's campaign manager
- Keith David as Lieutenant Dixon, Tom's superior officer
- Jack McGee as Gun Store Owner
- Greg Joung Paik as Choi Chin Gui, a human trafficker
- Alexis Rhee as Kim Lee, Choi Chin Gui's wife
- Daniel Dae Kim as Park
- Nona Gaye as Karen
- Bruce Kirby as "Pop" Ryan
- Tony Danza as Fred
- Kathleen York as Officer Johnson
- Sylva Kelegian as Nurse Hodges
- Marina Sirtis as Shereen, Farhad's wife
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