- The book has been optioned by Leonardo DiCaprio's production company, Appian Way Productions. James V. Hart, screenwriter for the film Contact and his son Jake Hart have been linked to the developing script.
- A calypso musical adaptation was presented by the Untitled Theater Company #61 in New York in 2008.
- Vonnegut collaborated with US composer Dave Soldier for a CD titled Ice-9 Ballads, featuring nine songs with lyrics taken from Cat's Cradle. Vonnegut narrated his lyrics to Soldier's music.
- A straight theatrical adaptation of the book was presented in Washington, DC in August and September 2010 by Longacre Lea Productions.
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