Dick's friend, K. W. Jeter, wrote three authorized Blade Runner novels that continue Deckard's story, attempting to resolve the differences between the film and Do Androids Dream of Electric Sheep?: Blade Runner 2: The Edge of Human (1995), Blade Runner 3: Replicant Night (1996), and Blade Runner 4: Eye and Talon (2000). By 1999, Stuart Hazeldine had written a sequel to Blade Runner based on The Edge of Human, titled Blade Runner Down; the project was shelved due to rights issues. Blade Runner co-author David Peoples wrote the 1998 action film Soldier, which was referred to by him as a "sidequel" or spiritual successor to the original film.
Scott considered developing a sequel, tentatively titled Metropolis. At the 2007 Comic-Con Scott again announced that he was considering a sequel to the film. Eagle Eye co-writer Travis Wright worked with producer Bud Yorkin for several years on the project. His colleague John Glenn, who left the project by 2008, stated the script explores the nature of the off-world colonies as well as what happens to the Tyrell Corporation in the wake of its founder's death.
In June 2009 The New York Times reported that Scott and his brother Tony Scott were working on a Blade Runner prequel, set in 2019. The prequel, Purefold, was planned as a series of 5–10 minute shorts, aimed first at the web and then perhaps television. Due to rights issues the proposed series was not to be linked too closely to the characters or events of the 1982 film. On February 7, 2010, it was announced that production on Purefold had ceased, due to funding problems. On March 4, 2011, io9 reported that Yorkin was developing a new Blade Runner film. It was also reported that month that director Christopher Nolan was the desired choice to make the film.
It was announced on August 18, 2011, that Scott was to direct a new Blade Runner movie, with filming to begin no earlier than 2013. Indications from producer Andrew Kosove were that Ford was unlikely to be involved in the project. Scott later said that the film was "liable to be a sequel" but without the previous cast, and that he was close to finding a writer that "might be able to help [him] deliver". On February 6, 2012, Kosove denied that any casting considerations had been made in response to buzz that Ford might reprise his role, saying, "It is absolutely, patently false that there has been any discussion about Harrison Ford being in Blade Runner. To be clear, what we are trying to do with Ridley now is go through the painstaking process of trying to break the back of the story ... The casting of the movie could not be further from our minds at this moment." When Scott was asked about the possibility of a sequel in October 2012, he said, "It's not a rumor—it's happening. With Harrison Ford? I don't know yet. Is he too old? Well, he was a Nexus-6 so we don't know how long he can live. And that's all I'm going to say at this stage."
In November 2014, Variety magazine reported that Scott was no longer the director for the film and would only fulfill a producer's role. Scott also revealed that Ford's character will only appear in "the third act" of the sequel. In February 2015, Alcon Entertainment confirmed that Scott will not be back to direct, and they were negotiating with Prisoners director Denis Villeneuve. Ford, however, will return, as will original writer Hampton Fancher, and the film is expected to enter production in mid-2016.