- Margaret Simon – the eleven-year-old protagonist
- Barbara Simon (born Hutchins) – Margaret's mother
- Herbert Simon – Margaret's father
- Sylvia Simon – Margaret's Jewish paternal grandmother
- Nancy Wheeler – Margaret's neighbor and first friend in New Jersey, a member of the Pre-Teen Sensations. She is also 11 years old
- Gretchen Potter – Margaret's friend and the first member of the Pre-Teen Sensations to get her period
- Janie Loomis – Margaret's friend and a member of the Pre-Teen Sensations
- Evan Wheeler – Nancy's older brother
- Moose Freed – Evan's friend who cuts the Simon family's lawn and is Margaret's crush
- Miles J. Benedict – Margaret's sixth-grade teacher
- Laura Danker – a classmate of Margaret's who is tall and developed for her age
- Philip Leroy – a classmate of Margaret's whom she likes at first
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