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Antigone has a few tragic flaws going for her, or rather against her. Her loyalty to the gods and her brother's memory means that she will have to be disloyal to King Creon.
Antigone is also pretty stubborn. That is kind of a good trait in a heroic sort of way but unfortunately her stubbornness gets herself in trouble but also risks other characters as well like Ismene and Haemon.
Antigone's modus operandi seems to be a reverence for all things dead, like Polynices, rather than herself or the people alive that she cares about.