The 1933 K.B.S. Productions Sherlock Holmes film, A Study in Scarlet, predates the publication of Ten Little Indians and follows a strikingly similar plot; it includes a scene where Holmes is shown a card with the hint: "Six little Indians ....bee stung one and then there were five"; the film predates the novel by six years. Though it is a Sherlock Holmes movie, the movie bears no resemblance to Arthur Conan Doyle's original story of the same name. In this case, the rhyme refers to "Ten Little Fat Boys". The author of the movie's screenplay, Robert Florey, "doubted that [Christie] had seen A Study in Scarlet, but he regarded it as a compliment if it had helped inspire her".
Several parodies have been made. As early as autumn 1942, "World's Finest Comics" (#7, Fall Issue) had a Superman story by Jerry Siegel and Joe Shuster called "The Eight Doomed Men" which used Christie's basic structure and even borrowed a number of her victim's backgrounds, although Superman intervened to rescue half of the intended victims and the killer's motivation was changed to specific revenge. Siegel and Shuster anticipated the 1966 film by moving the locale to a mountain cabin and tossed in a Zeppelin-like dirigible – one location not yet used in adaptations of the story. Another parody, the 1976 Broadway musical Something's Afoot, stars Tessie O'Shea as a female sleuth resembling Miss Marple. Something's Afoot takes place in a remote English estate, where six guests have been invited for the weekend. The guests, as well as three servants and a young man who claims to have wandered innocently onto the estate, are then murdered one by one, several in full view of the audience, with the murderer's surprise identity revealed at the end. For an encore, the murdered cast members perform a song, "I Owe It All to Agatha Christie".
In television, the story was spoofed in the 1966 Get Smart episode "Hoo Done It", which featured guest star Joey Forman as "Detective Harry Hoo", a parody of Charlie Chan. An episode of Spider-Man and his Amazing Friends titled "7 Little Superheroes" is, being a children's show, a murder-free adaptation of the story. The Remington Steele episode "Steele Trap" and The Adventures of Brisco County, Jr. episode "Bounty Hunters Convention" were other television episodes inspired by the story. In the 1967 The Avengers adaption "The Superlative Seven" John Steed is invited to a costume party aboard a chartered aeroplane. The aeroplane is being flown by remote control. Steed and the six other fancy-dressed guests, who are specialists in various combat styles, eventually land on a deserted island where they are informed that one of them is a trained assassin trying to kill them all. When the first murder is committed, Steed observes "Looks as though his back was broken". To which an off-screen protagonist responds, over a speaker, "Quite right, Mr Steed. And then there were six". CSI:Crime Scene Investigation based an episode of the show's second season under the same name focusing on a gang of armed robbers stealing from casinos outside the Las Vegas metropolitan area with each criminal killing a member of the gang to keep more of the proceeds.
In 2014 YouTube Creators Rooster Teeth did a version named 'Ten Little Roosters', which uses the same premise of a rhyme to predict the murder of 10 people. Competitions were run while the series was originally aired where viewers could predict which characters they thought would be killed at which point of the story.