Mike Walker adapted Anansi Boys into a radio play for the BBC World Service. It stars Lenny Henry as Spider and Fat Charlie, Matt Lucas as Grahame Coats and Tiger, Rudolph Walker (best known as Patrick Trueman on British soap opera EastEnders) as Anansi, Doña Croll as Mrs Noah and the Bird Woman, Tameka Empson as Mrs Higgler, Petra Letang as Rosie, Jocelyn Jee Esien as Daisy, and Ben Crowe as Cabbies and other voices. It was broadcast on 17 November 2007. The original sound track was composed by Danish composer in residence Nicolai Abrahamsen. It was directed by Anne Edyvean (who also worked on the radio 3 adaptation of Signal to Noise in 1996).
Neil Gaiman stated that he was displeased with the BBC radio adaptation, because "budget cutbacks and less broadcasting time for drama [have caused BBC to decide] it would have to be an hour-long adaptation. And bad things happen when novels get cut down to an hour. So despite a really terrific cast and production and as solid a script as could be in the circumstances, I was not happy. It felt like one of those Readers' Digest condensed books". Gaiman attributed to this sentiment his willingness to write the script of the Anansi Boys movie adaptation, saying that "I normally say no to adapting my own stuff into film. But I wanted an Anansi Boys adaptation I could be proud of, and the radio adaption had left me wanting to go: No, this is what I meant".