This classic play was adapted by Arthur Miller in the 1950s in a production that opened at the Broadhurst Theater on December 28, 1950. It starred Academy Award winner Fredric March and his wife Florence Eldridge as well as Morris Carnovsky; future Oscar winner Rod Steiger was a "townsperson." Miller's adaptation was presented on National Educational Television in 1966, in a production starring James Daly. It was also made into a movie of the same name in 1978, starring Steve McQueen. The BBC then cast Robert Urquhart as "Tom Stockman" in their 1980 TV version, adapting the story and the cast names to reflect it now being set in a Scottish town.
A version was produced for Australian television in 1958.
Satyajit Ray's 1989 film Ganashatru, was also based on this play. In 1990, PBS produced the play for their show American Playhouse, starring William Anton and John Glover.
In 2007 Ouriel Zohar creates his troupe Compagnie Ouriel Zohar with An Enemy of the People in Paris, an adaptation for two actors only. First performance in Paris, then Fréjus, Besançon in 2008, Liège Belgium Minsk Belarus Valleyfield in Canada 2009, Porto Heli in Greece in 2010.
A stage version starring Richard Thomas and Boyd Gaines opened in New York in September 2012.
An Enemy of the People (with the subtitle The strongest one is the one who stands alone)—a Norwegian film issued in 2004 and directed by Erik Skjoldbjærg—is an adaptation of Ibsen's play.
The play was the indirect inspiration for the blockbuster movie Jaws.
In early 2013, an adaptation was made in Egypt entitled "عدو الشعب". Translated from Arabic, the title is Enemy of the people or A Public Enemy. It was a theater production organized and directed by Nora Amin (who herself plays the role of Doctor Stockman's wife) and starring Tarek El-Dewiri as Doctor Thomas Stockman. It was translated into colloquial Arabic and featured a rock-themed soundtrack played live on-set. It received various positive reviews and was jointly sponsored by the Norwegian Embassy in Cairo and the Ibsen Studies Center in Norway. The show came at a time where Egypt and the capital, Cairo are plunged into deep turmoil and the play carries serious political relevance in post-revolutionary Egypt.  
In May 2013, the Young Vic theatre in London presented a version by David Harrower titled Public Enemy, directed by Richard Jones.
The play was staged in 2013, between October and December, in the Teatro da Comuna in Lisbon.