An unabridged four cassette audio edition, read by the author, was released in 1994 by Listening Library, ISBN 0-8072-7587-5. A 50th anniversary edition recorded by Hope Davis was due to be released in January 2013.
A television adaptation of the novel was made by a collaboration of Canadian production companies to be distributed in America by Disney. The movie was directed by John Kent Harrison, with a teleplay by Susan Shilliday. It cast Katie Stuart as Meg Murry, and Alfre Woodard, Alison Elliott, and Kate Nelligan as Mrs Whatsit, Who, and Which.
In an interview with Newsweek, when L'Engle was asked if the film "met her expectations" she said, "Yes, I expected it to be bad, and it is."
The film was subsequently released on DVD. The special features included a "very rare" interview with Madeleine L'Engle, discussing the novel.
In 2010, it was announced that Disney retained film rights to remake the novel. Following the success of Tim Burton's Alice in Wonderland, Disney announced hiring Jeff Stockwell to write the screenplay for Cary Granat and his new Bedrock Studios. Cary Granat had previously worked with Disney on the Chronicles of Narnia and Bridge to Terabithia films. The project's budget is $35 million, which the company compares to District 9 and Bridge to Terabithia, both of which had less than $30 million. On August 5, 2014, Jennifer Lee was announced as the screenwriter taking over from Stockwell, who wrote the first draft.
The novel was adapted as a play by John Glore in 2010. It was written for six actors playing twelve parts. One actor plays Mrs Whatsit, the Man with Red Eyes, and Camazotz Man. Dr. Kate Murry, Mrs Who, Camazotz Woman and Aunt Beast also share one performer. The stage adaptation premiered in Costa Mesa, California, with productions in Bethesda, Maryland; Cincinnati; Philadelphia; Orlando; Portland, Oregon; and other cities.
A new adaptation by Tracy Young will premiere at the Oregon Shakespeare Festival in April 2014.
In 1992, OperaDelaware (known for frequently adapting children's books) staged an opera based on A Wrinkle in Time written by Libby Larsen with a libretto by Walter Green. The review in Philly.com stated "The composer does not place arias and set pieces, but conversational ensembles with spoken dialogue that made the young daughter's climactic but concise song about familial love all the more imposing."
In 2010, Hope Larson announced that she was writing and illustrating the official graphic novel version of the book. This version was published by Farrar, Straus & Giroux in October 2012.