In his Naked Is the Best Disguise (1974), Samuel Rosenberg notes the similarity between Jefferson Hope's tracking of Enoch Drebber and a sequence in James Joyce's novel Ulysses, though of course Joyce's work did not begin to appear in print until 1918. Several other associations between Conan Doyle and Joyce are also listed in Rosenberg's book.
The British fantasy and comic book writer Neil Gaiman adapted this story to the universe of horror writer H. P. Lovecraft's Cthulhu Mythos. The new short story is titled "A Study in Emerald" (2004) and is modelled with a parallel structure.
In Garage Sale Mystery: The Novel Murders (2016), the second murder is an imitation of this murder.
In The Great Ace Attorney 2: Resolve, a character by the name of Enoch Drebber appears in the third case. Rather than a Mormon that forced a woman into an abusive marriage and was killed for it, Drebber is instead a brilliant scientist and engineer who worked on a device to get revenge on the man that ruined his life.
