California punk rock band Lagwagon based the song "Owen Meaney" from their 1998 album Let's Talk About Feelings on the book.
The band Jimmy Eat World also based the song "Goodbye Sky Harbor" from their 1999 album Clarity on the book.
In the movie Milk Money, the elementary school is named Owen Meany Elementary.
Former Los Angeles Lakers coach Phil Jackson has passed out this book to his team in the past as part of his ritual of assigning readings to players.
Canadian musician Ryan Granville-Martin wrote an instrumental composition entitled "A Prayer for Owen Meany" for his 2013 release Mouthparts and Wings.