The novel was adapted into All the Way Home, a 1961 Pulitzer Prize-winning play by Tad Mosel.
The movie All The Way Home (1963) was adapted by Philip H. Reisman, Jr. from the Agee novel and the Mosel play. It was filmed in the same neighborhood where Agee grew up in Knoxville. Produced by David Susskind and directed by Alex Segal, it stars Robert Preston, Jean Simmons and Pat Hingle.
A PBS TV movie version, filmed in Tennessee and starring Annabeth Gish, aired in 2002.
Samuel Barber wrote Knoxville: Summer of 1915 (1947, revised 1950) on commission from the American soprano Eleanor Steber, who had asked for a work for soprano with orchestra.