James Blish commented that while Clarke's narrative provided essential elements of the story that Kubrick ignored or glossed over, "The novel has very little of the poetry of the picture" and "lacks most of the picture's strengths", but that "it has to be read before one can understand the picture".[6]
Eliot Fremont-Smith reviewed the book positively in the New York Times, stating that it was "a fantasy by a master who is as deft at generating accelerating, almost painful suspense as he is knowledgeable and accurate (and fascinating) about the technical and human details of space flight and exploration".[7]